Via IGN:
According to Howard, showrunners Graham Wagner and Geneva Robertson-Dworet came to him with the idea to blow up Shady Sands, something Howard says shocked him at first. But the event would serve as a catalyst for the main characters of the Fallout show and the showrunners worked with Howard and the Bethesda team to ensure it remained consistent with the games.
“And we talked through it and it was, ‘This would be a pretty impactful story moment that a lot of things anchor on,"' Howard says. But for anyone confused about how the city could be blown up by the time the show takes place, Howard explains all the details of the timeline should line up.
“We’re careful about the timeline,” he says.
“There might be a little bit of confusion in some places. But everything that happened in the previous games, including New Vegas, happened. We’re very careful about that.” “All I can say is we’re threading it tighter there, but the bombs fall just after the events of New Vegas.”