Ngl ESO has been like this. Summerset DLC had a character named Alchemy who is revealed to be her brother's biological twin is a trans woman.
Argonians in general can use the hist to change their sex, two characters in ESO even have a relation to it.
Chal-Maht and
Kud-Nakal.
Vivec from Morrowind is biologically intersex, both male and female, which he did after getting his godlike powers.
Bosmer have
The Silvenar
The list can go on and on and on.
Here is a wiki detailing all instances of LGBTQ in the entire Elder Scrolls franchise.