That actually doesn't mean much. Japanese people are very much about respecting seniority and authority, if he went out and said "microsoft wants to work on smaller games now" it would be unfathomable and seen as disgraceful. If this quote had come out before the acquisition maybe you'd have a point.
He has literally been saying that since the studio was created. No need to be a contrarian for the sake of it.
The ability to make bigger and smaller projects and train young directors to lead projects was his vision for Tango since establishing it.
This is from 2014.
Mikami envisioned the studio as a place that could sustain more than one project at a time, in order to create a culture not tied to any one genre and offer more opportunities for young directors. It would develop some small projects, some large.
Shinji Mikami and the fountain of youth
The creator of Resident Evil saw a lack of opportunities for young game directors in Japan. So he started a company to create some.
www.polygon.com