A new Uncharted game too much to ask for?
No, pretty likely they are working on it, specially after the hit success of the movie.
The thing is that ND/Sony's woke religiion has a sexist/racists/heterophobic issue with having white male heterosexual protagonists, so weren't engaged to continue with Uncharted going forward with Nate as main character. They tried to retire him and replace him with female leads in Lost Legacy but since these characters didn't have enough charisma and was a smaller game, sales were way lower in Nate's games.
On top of this, TLOU huge success in sales/reviews/awards engaged them to focus on TLOU for a while -obviously removing its white heterosexual male protagonist.
And well, they didn't have a new IP since a lot of time ago, so pretty likely are working on a new IP.
ND moved the next Uncharted to Bend, who later prefered to make their own IP instead, which mixed with the success of the movie made ND or Sony want to make a new Uncharted inside ND, something they maybe needed to do to financially justify to allow ND grow to the point of being able to work on 3 big games at the same time while until 2019 (when branched out the TLOU2MP into a new game) were only working in 1.
I assume ND is working on an Uncharted game with the girl as main protagonist but maybe also with some appearance of Nate in a secondary role. It may be codeveloped/supported by some other team as could be Bluepoint (who made the remasters of the Nathan Drake Collection).
Regarding Nathan Drake Collection, I assume Iron Galaxy now may be working on its PS5+PC version.