There must be loads of people in the wings at the company that can take over his position and i would imagine many of them are incredibly talented.The DEI team will make sure he's replaced by a more inclusive choice, preferably someone who has demonstrated their ability to not work too much so they don't stress out the rest of the studio.
I don't know that much about Naughty Dog, but Uncharted 2, for example, was done by that Amy Hennig chick; that particular game was incredible. ( i know she left the company but there most be loads of good people like that still there)